Comparative Study between Intact PTH and Fragments of PTH in Patients on Hemodialysis and CAPD
| Autor: | P Catalan, Rafael Selgas, Miguel Jl, G Balaguer, M Ausejo, Martínez Me, M L Gonzalez |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
endocrine system
medicine.medical_specialty Resuscitation medicine.medical_treatment 030232 urology & nephrology Parathyroid hormone chemistry.chemical_element Calcium urologic and male genital diseases Peritoneal dialysis 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine In patient 030212 general & internal medicine business.industry Continuous ambulatory peritoneal dialysis General Medicine Intact pth Endocrinology chemistry Nephrology Hemodialysis business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis. 11:137-140 |
| ISSN: | 1718-4304 0896-8608 |
| DOI: | 10.1177/089686089101100207 |
| Popis: | Twenty-nine patients on hemodialysis (HD) and 29 patients on continuous ambulatory peritoneal dialysis (CAPD) were studied. Serum calcium and phosphorous levels were similar in the 2 groups. Serum parathyroid hormone (PTH) levels were determined by 4 different methods. Mid-molecule PTH levels were higher in HD (1099.5 +/- 876.8 pmol/L) than in CAPD patients (541.0 +/- 138.8 pmol/L), p less than 0.001, while intact PTH levels were similar. The ratio MM-PTH/Intact PTH was higher in HD (55.2 +/- 29.0) than in CAPD patients (39.0 +/- 20.0), where p less than 0.01. In patients with similar C-PTH, those on CAPD had higher levels of intact PTH (46.0 +/- 27.0 pmol/L) than those in HD (29.3 +/- 29.0 pmol/L), p less than 0.01. The ratio C-PTH/intact PTH was higher in HD (104.9 +/- 39.6) than in CAPD patients (59.3 +/- 32.3), p less than 0.001. The Peritoneal Saturation Index (PSI) of MM-PTH was 23.4 +/- 12%, and it showed a hyperbolic correlation in respect to MM-PTH serum levels. We concluded that CAPD can modify the plasma C-PTH and MM-PTH serum levels by peritoneal losses of these fragments. |
| Databáze: | OpenAIRE |
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