Philadelphia chromosome (Ph1)-negative chronic myelogenous leukemia (CML): a clonal disease with origin in a multipotent stem cell

Autor:	Philip J. Fialkow, Robert W. McGuffin, John R. Neefe, Ronald A. Sacher, Robert Jacobson, Jack W. Singer
Rok vydání:	1980
Předmět:	Immunology Cell Biology Hematology Eosinophil Biology medicine.disease Philadelphia chromosome Biochemistry Peripheral blood mononuclear cell Leukemia Haematopoiesis medicine.anatomical_structure Multipotent Stem Cell hemic and lymphatic diseases medicine Stem cell Chronic myelogenous leukemia
Zdroj:	Blood. 56:70-73
ISSN:	1528-0020 0006-4971
DOI:	10.1182/blood.v56.1.70.70
Popis:	It has been shown with glucose 6-phosphate dehydrogenase (G-6-PD) mosaicism that Ph1-positive chronic myelogenous leukemia (CML) is a clonal disease that involves multipotent hematopoietic stem cells. We now report G-6-PD studies of a 79-yr-old woman with Ph1-negative CML. Equal amounts of B and A-type activities were found in nonhematopoietic tissues, indicating that the patient was heterozygous for G-6-PD. In contrast, only A-type G-6-PD was found in marrow cells, blood erythrocytes, leukocytes, and platelets and in granulocyte-monocyte and eosinophil colonies grown from blood mononuclear cells. Unlike most cases of PH1-positive CML, colony growth in this patient increased during blastic transformation and the colonies contained only immature monocytic cells. The data indicate that in this patient, Ph1-negative CML is similar to the Ph1-positive form of the disease in involvement of multipotent stem cells and probable clonal origin, but the two disorders differ in the rapidity with which they enter blastic transformation and in the pattern of granulocyte-monocyte colony growth at that time.
Databáze:	OpenAIRE
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