Impact of Chronic Oral Administration of Silver Nanoparticles on Cognitive Abilities of Mice
| Autor: | Vyacheslav A. Demin, Sergey S. Pavlov, Marina Frontasyeva, Inga Zinicovscaia, A. L. Ivlieva, D. A. Rogatkin, A. A. Glazkov, E. N. Petritskaya |
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| Rok vydání: | 2021 |
| Předmět: |
Physics
Nuclear and High Energy Physics Radiation 010308 nuclear & particles physics Morris water navigation task Cognition Pharmacology 01 natural sciences Atomic and Molecular Physics and Optics Silver nanoparticle Behavioral test Oral administration 0103 physical sciences Radiology Nuclear Medicine and imaging 010306 general physics |
| Zdroj: | Physics of Particles and Nuclei Letters. 18:250-265 |
| ISSN: | 1531-8567 1547-4771 |
| DOI: | 10.1134/s1547477121020072 |
| Popis: | To assess the effect of silver nanoparticles on mice cognitive abilities, daily, up to 4-month period, experimental mice were administrated with silver nanoparticles solution. Accumulation of silver in brain was assessed by neutron activation analysis. Cognitive abilities in mice before and after silver nanoparticles administration were evaluated in the Morris water maze behavioral test. No significant differences in the amounts of silver accumulated in brain were found between capable and incapable animals. Silver accumulation in brain of experimental animals in 4-months experiment was higher than in 2-months experiment for both groups. In the main Morris water maze behavioral test at the control points of 2 and 4 months no statistically significant differences were found in the parameters of treks between experimental and control animals. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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