A Large Cross-Sectional Survey Study of the Prevalence of Alopecia Areata in the United States
| Autor: | Joseph C. Cappelleri, Kathryn Anastassopoulos, Laura Kauffman, Michael Benigno, Elena Peeva, Jennifer Lapthorn, Arash Mostaghimi, Linda H. Chen, Peter M Wahl, Margarita Udall, Shoshana R Daniel, Pratibha Chander |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Cross-sectional study business.industry Alopecia totalis Population Prevalence Dermatology Alopecia areata medicine.disease 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Quality of life 030220 oncology & carcinogenesis Alopecia universalis Internal medicine Epidemiology medicine education business |
| Zdroj: | Clinical, Cosmetic and Investigational Dermatology. 13:259-266 |
| ISSN: | 1178-7015 |
| DOI: | 10.2147/ccid.s245649 |
| Popis: | Purpose Alopecia areata (AA) is an autoimmune disease characterized by the development of non-scarring alopecia. The prevalence is not well known, and estimates vary considerably with no recent estimates in the United States (US). The objective of this study was to define the current AA point prevalence estimate among the general population in the US overall and by severity. Patients and methods We administered an online, cross-sectional survey to a representative sample of the US population. Participants self-screening as positive for AA using the Alopecia Assessment Tool (ALTO) also completed the Severity of Alopecia Tool (SALT) to measure the severity of disease as a percent of scalp hair loss. Self-reported AA participants were invited to upload photographs for adjudication of AA by 3 clinicians. Results The average age of participants was 43 years. Approximately half of the participants (49.2%) were male, and the majority were white (77.1%) and not of Hispanic origin (93.2%). Among the 511 self-reported AA participants, 104 (20.4%) uploaded photographs for clinician evaluation. Clinician-adjudicated point prevalence of AA was 0.21% (95% CI: 0.17%, 0.25%) overall, 0.12% (95% CI: 0.09%, 0.15%) for "mild" disease (≤50% SALT score), and 0.09% (95% CI: 0.06%, 0.11%) for "moderate to severe" disease (>50% SALT score) with 0.04% (95% CI: 0.02%, 0.06%) for the alopecia totalis/alopecia universalis (100% SALT score) "moderate to severe" subgroup. The average SALT score was 44.4% overall, 8.8% for "mild", and 93.4% for "moderate to severe". Conclusion This study suggests that the current AA prevalence in the US is similar to the upper estimates from the 1970s at approximately 0.21% (700,000 persons) with the current prevalence of "moderate to severe" disease at approximately 0.09% (300,000 persons). Given this prevalence and the substantial impact of AA on quality of life, the burden of AA within the US is considerable. |
| Databáze: | OpenAIRE |
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