Complex-Induced Proximity Effect in the Regioselective Lithiation of Pyridine Derivatives

Autor:	Yoganjaneyulu Kasetti, Prasad V. Bharatam, Jaspreet S. Dhau, Amritpal Singh
Rok vydání:	2012
Předmět:	chemistry.chemical_compound chemistry Organic Chemistry Pyridine Regioselectivity Physical and Theoretical Chemistry Ring (chemistry) Photochemistry Medicinal chemistry Proximity effect (atomic physics)
Zdroj:	European Journal of Organic Chemistry. 2012:1746-1752
ISSN:	1434-193X
DOI:	10.1002/ejoc.201101592
Popis:	The regioselective ring lithiation of BF3-complexed 3-picoline (1a), 3,4-lutidine (1b), and 3,5-lutidine (1c) was studied. The dilithiation of 1a, 1b, and 1c was also investigated to experimentally explore the relative preference of the sites on the substituted pyridine ring for lithiation. The role of the complex-induced proximity effect (CIPE) for inducing lithiation in these moieties was investigated using both experimental and computational studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a5add46ed9f661cf3e4e35ccb04b084c https://doi.org/10.1002/ejoc.201101592 Zobrazit plný text záznamu Plný text