Reactivity of 2,6-Dichloropurine Ribonucleoside Studied by 35Cl NQR Spectroscopy
Autor: | M. Ostafin, O. Kh. Poleshchuk, I. Dobak, J. Milecki, B. Nogaj |
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Rok vydání: | 2008 |
Předmět: | |
Zdroj: | Applied Magnetic Resonance. 34:47-53 |
ISSN: | 1613-7507 0937-9347 |
Popis: | 2,6-Dichloropurine ribonucleoside is a precursor in the potential synthesis of anticancer and antiviral drugs. 35Cl nuclear quadrupole resonance (NQR) studies on electronic structure and the character of C–Cl bonds may provide a valuable information about the difference in reactivity of chlorine atoms present in this compound. In this work 35Cl NQR frequencies, asymmetry parameters and double-bond character for both C–Cl bonds have been determined experimentally. These parameters were then compared with the corresponding theoretical values obtained by means of the density functional theory. |
Databáze: | OpenAIRE |
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