Erratum to: Magnetic iron oxide nanoparticles accelerate osteogenic differentiation of mesenchymal stem cells via modulation of long noncoding RNA INZEB2
| Autor: | Shikang Lin, Meng Cao, Fang Ma, Qiwei Wang, Ning Gu, Yan Li, Bo Chen |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Chemistry Mesenchymal stem cell Nanotechnology 02 engineering and technology 021001 nanoscience & nanotechnology Condensed Matter Physics Regenerative medicine Atomic and Molecular Physics and Optics Long non-coding RNA Cell biology 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Downregulation and upregulation Transcription (biology) Gene expression General Materials Science Electrical and Electronic Engineering Stem cell 0210 nano-technology Iron oxide nanoparticles |
| Zdroj: | Nano Research. 10:2192-2192 |
| ISSN: | 1998-0000 1998-0124 |
| DOI: | 10.1007/s12274-017-1566-7 |
| Popis: | Nanomaterials are increasingly used for biomedical applications; thus, it is important to understand their biological effects. Previous studies suggested that magnetic iron oxide nanoparticles (IONPs) have tissue-repairing effects. In the present study, we explored cellular effects of IONPs in mesenchymal stem cells (MSCs) and identified the underlying molecular mechanisms. The results showed that our as-prepared IONPs were structurally stable in MSCs and promoted osteogenic differentiation of MSCs as whole particles. Moreover, at the molecular level, we compared the gene expression of MSCs with or without IONP exposure and showed that IONPs upregulated long noncoding RNA INZEB2, which is indispensable for maintaining osteogenesis by MSCs. Furthermore, overexpression of INZEB2 downregulated ZEB2, a factor necessary to repress BMP/Smad-dependent osteogenic transcription. We also demonstrated that the essential role of INZEB2 in osteogenic differentiation was ZEB2-dependent. In summary, we elucidated the molecular basis of IONPs’ effects on MSCs; these findings may serve as a meaningful theoretical foundation for applications of stem cells to regenerative medicine. |
| Databáze: | OpenAIRE |
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