Self-assembled mixed micelle loaded with natural pyrethrins as an intelligent nano-insecticide with a novel temperature-responsive release mode
| Autor: | Liu Shanzhi, Xing Zhang, Mengmeng Jing, Zhou Yiwan, Zhiqing Ma, Jun-Tao Feng, Hua Wu, Yunfei Zhang, Wei Chen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Lactide
General Chemical Engineering 02 engineering and technology General Chemistry Polyethylene glycol 010402 general chemistry 021001 nanoscience & nanotechnology Methacrylate Mixed micelle 01 natural sciences Controlled release Industrial and Manufacturing Engineering 0104 chemical sciences Self assembled chemistry.chemical_compound chemistry Pyrethrin Nano Environmental Chemistry Organic chemistry 0210 nano-technology |
| Zdroj: | Chemical Engineering Journal. 361:1381-1391 |
| ISSN: | 1385-8947 |
| DOI: | 10.1016/j.cej.2018.10.132 |
| Popis: | Nanotechnology has recently attracted growing interest in the encapsulation of botanical insecticides for sustainable pest control. Biocompatible, biodegradable, and stimuli-responsive devices, however, were scarcely reported in the field of intelligent formulations of botanical insecticides. In the present study, a temperature-responsive mixed micelle (MMs–Pys–7) was developed for controlled release of pyrethrins by cooperative assembly of poly[2-(2-Methoxyethoxy) ethyl methacrylate-co-Octadecyl methacrylate] (P(MEO2MA94–co–ODA6)), monomethoxy (polyethylene glycol)13-poly( D , L -Lactide-co-glycolide) (mPEG13–b–PLGA5–3) and monomethoxy (polyethylene glycol)45-poly( D , L -Lactide) (mPEG45–b–PLA28) in water. This nanodevice could protect the encapsulated pyrethrins from ultraviolet degradation at 26 °C effectively. It also underwent a phase transition process in water from solution state to turbid state with temperature rising from 13 to 26 °C. By inducing this structural change, MMs–Pys–7 could regulate the pyrethrin release amounts to adapt to the larval mosquito population variations along with the ambient temperature changes. Therefore, MMs–Pys–7 exhibited a higher larvicidal activity against Culex pipiens pallens at 26 °C than that at 14 °C or 18 °C. Compared with a commercial pyrethrin formulation (EW–Pys), MMs–Pys–7 was more toxic to C. p. pallens larvae at 26 °C after 24-h exposure but less toxic at 14 °C. Moreover, MMs–Pys–7 also exhibited a longer-lasting larvicidal activity under natural conditions as compared to EW–Pys. These results suggest that MMs–Pys–7 has great potential to be developed as an intelligent nano-insecticide for mosquito control and that the controlled release mode established in this study can be applied to develop more smart formulations of botanical insecticides of application potential. |
| Databáze: | OpenAIRE |
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