POLY ALKYL CYANOACRYLATE NANOPARTICLES AS DELIVERY VEHICLE IN COMBATING DISEASES
| Autor: | Ardhendu K. Mandal |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
0303 health sciences endocrine system diseases Chemistry Delivery vehicle Nanoparticle 02 engineering and technology 021001 nanoscience & nanotechnology Combinatorial chemistry law.invention 03 medical and health sciences Cyanoacrylate law 0210 nano-technology Alkyl 030304 developmental biology |
| Zdroj: | INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH. :15-19 |
| DOI: | 10.36106/ijsr/7136990 |
| Popis: | The major problems in drug delivery to specific diseased sites possess drug-resistance, drug-toxicity, biological barriers and non-specificity to the target-cells observed among patients worldwide. To overcome these barriers, the biodegradable poly alkyl cyanoacrylate (PACA) nanocarriers have been used, while a core made up of PACA is functionalized with biologically active ligands such as cargos, biotin and antibody for enabling specific targeting, and stabilized with outer polyethylene glycol or surfactants in combating cancer, neurodegenerative and infectious diseases. The review demonstrates mainly the synthesis, functionalizations and the biomedical applications of PACA nanoparticles against various diseases to consider them as potent delivery vehicle. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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