Effects of in Vivo Exposure to Glucocorticoids on Pituitary, Serum, and Messenger Ribonucleic Acid Levels of the Gonadotropin Hormones FSH and LH in Male
| Autor: | Joanne M. McAndrews, Sonia J. Ringstrom |
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| Rok vydání: | 1996 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.drug_class Antagonist Gonadotropic cell chemistry.chemical_compound Endocrinology chemistry In vivo Corticosterone Internal medicine medicine Gonadotropin Luteinizing hormone hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug Hormone |
| Popis: | Publisher Summary Glucocorticoids (both corticosterone, the native glucocorticoid in the rat, and cortisol) have different effects on the two anterior pituitary hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which regulate reproductive processes. Sustained exposure to high levels of glucocorticoids, such as those present in a stress response, suppresses serum levels of LH, while not affecting or only minimally affecting pituitary content of LH in both sexes. This suggests that glucocorticoids inhibit the release of LH from the gonadotropes. In contrast, high levels of circulating glucocorticoids do not affect or only slightly affect serum levels of FSH, but increase pituitary content of FSH in both sexes. This indicates that glucocorticoids either increase synthesis or block the degradation of FSH in the gonadotropes. Treatment of male rats with elevated levels of cortisol caused a decrease in serum LH, but pituitary content of LH was not affected; immunoreactive serum FSH was not affected in males treated with cortisol; pituitary content of FSH was increased in male rats treated with cortisol; and cortisol treatment completely reversed the effects of a gonadotropin-releasing hormone (GnRH) antagonist on pituitary FSH in female rats. |
| Databáze: | OpenAIRE |
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