Targeted anti-inflammatory therapy effect on various indicators of the psoriatic arthritis activity: Moscow Unified Arthritis Registry (MUAR) data
| Autor: | E.I. Shmidt, E.N. Koltsova, G.V. Lukina, K.A. Lytkina, E.V. Zhilyaev |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Russian Medical Inquiry. 5:78-83 |
| ISSN: | 2686-9918 2587-6821 |
| DOI: | 10.32364/2587-6821-2021-5-2-78-83 |
| Popis: | Background: the number of genetically engineered biological drugs and targeted synthetic drugs for the treatment of psoriatic arthritis (PA) is rapidly increasing. Data on their comparative efficacy is limited. The results of individual studies suggest that the drugs may show different efficacy concerning different disease manifestations (arthritis, spondylitis, entesitis, cutaneous and nail lesions). Aim: to compare the effect of targeted drugs on the results achieved in different PA domains in real clinical practice. Patients and Methods: the data were taken from the Moscow Unified Arthritis Registry (MUAR). We analyzed treatment episodes in which there was a completed visit no earlier than 6 months from therapy initiation with targeted drug (adalimumab, certolizumab pegol, etanercept, golimumab, infliximab, tofacitinib, ustekinumab). Drug comparison was carried out according to the achieved values of the DAS-28, BASDAI, MASES, LEI, DLQI, PASI and BSA indices. The most significant confounders (factors that characterize the patient and are significantly related to the studied indicator) were established for each group of indicators to eliminate the impact of differences between patients who received different drugs. The comparisons were adjusted for confounders. Results: the analysis included 184 treatment episodes with targeted drugs in 156 patients with PA. There were no significant differences between the drugs in their effect on the following domains: «joints» domain (DAS-28), «spine/entheses» domain (BASDAI, MASKS, LEI), «skin» domain (DLQI, PASI, BSA). Conclusion: the achieved values of activity indicators concerning the involvement of joint, spine, entheses and skin in patients with PA didn’t significantly differ when treated with various targeted drugs. KEYWORDS: psoriatic arthritis, enthesitis, spondylitis, sacroiliitis, targeted therapy, treatment efficacy, confounder. FOR CITATION: Lytkina K.A., Lukina G.V., Koltsova E.N. et al. Targeted anti-inflammatory therapy effect on various indicators of the psoriatic arthritis activity: Moscow Unified Arthritis Registry (MUAR) data. Russian Medical Inquiry. 2021;5(2):78–83. DOI: 10.32364/2587-6821- 2021-5-2-78-83. |
| Databáze: | OpenAIRE |
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