Cyclodextrins, Their Value in Pharmaceutical Technology

Autor:	C. Vaution, F. Glomot, D. Duchěne
Rok vydání:	1986
Předmět:	Pharmacology Active ingredient Chemistry Organic Chemistry Pharmaceutical Science Combinatorial chemistry Inclusion compound Hydrolysis chemistry.chemical_compound Membrane Stability constants of complexes Drug Discovery Organic chemistry Molecule Solubility Dissolution
Zdroj:	Drug Development and Industrial Pharmacy. 12:2193-2215
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639048609042630
Popis:	Cyclodextrins are cyclic oligosaccharides consisting of a variable number of glucose units (usually 6 to 81. The ring formed by cyclodextrins is externally very hydrophilic and relatively apolar internally. In liquid or solid medium, these molecules are capable of forming inclusion compounds with many other molecules. The inclusion compounds thus formed display interesting properties in comparison with the starting molecule.In fact, inclusion may increase the stability of the guest molecules. Greater stability may be shown towards heat, resulting in lower volatility or higher thermal resistance. Greater stability may also be oxidation resistance. It may also concern the products in solution, whose hydrolysis may, in certain cases, be inhibited to varying degrees. For relatively insoluble active ingredients, inclusion may improve the solubility or dissolution rate. Depending on the stability constant of the inclusion compound formed, a better passage of the active ingredient through membranes may be observ...
Databáze:	OpenAIRE
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