Serotonin Deficiency and Alcohol Use Disorders
| Autor: | Katherine Dodson, B.D. Sachs |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Chronic alcohol abuse Aggression Alcohol Impulsivity Serotonergic Excessive alcohol consumption 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine chemistry mental disorders medicine Serotonin medicine.symptom Psychology Psychiatry Alcohol consumption 030217 neurology & neurosurgery |
| DOI: | 10.1016/b978-0-12-805373-7.00018-9 |
| Popis: | Alcohol use disorders (AUDs) are thought to result from complex interplay between genetic and environmental factors, but the exact neurobiological underpinnings of these disorders have been difficult to establish. Although there is ample evidence documenting serotonergic dysfunction in AUD patients, whether the serotonergic abnormalities observed in AUD populations are the cause of excessive alcohol consumption or the result of chronic alcohol abuse remains controversial. This chapter reviews the preclinical and clinical data suggesting that low levels of brain serotonin could contribute to high levels of alcohol consumption along with impulsive and/or aggressive behavior, which are hallmarks of Cloninger's Type 2 alcoholic subtype. The potential of further subtyping AUD populations as a means to facilitate the identification of underlying pathophysiological processes and to improve treatment selection is also discussed. |
| Databáze: | OpenAIRE |
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