Regio- and diastereoselective synthesis of N-substituted 2-acyl-3-aryl-3,5-dihydrofuro[3,2-c]pyridin-4(2H)-ones

Autor:	P. E. Krasnikov, Yuri N. Klimochkin, Evgeny А. Kvetkin, Vitaly А. Osyanin, Dmitry V. Osipov
Rok vydání:	2020
Předmět:	010405 organic chemistry Chemistry Aryl Organic Chemistry Condensation 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound Intramolecular force Nucleophilic substitution Knoevenagel condensation Pyridinium
Zdroj:	Chemistry of Heterocyclic Compounds. 56:1423-1428
ISSN:	1573-8353 0009-3122
DOI:	10.1007/s10593-020-02832-z
Popis:	The three-component condensation of pyridinium acylmethylides generated in situ with aromatic aldehydes and 4-hydroxy-6-methylpyridones gave a series of 2-acyl-3-aryl-3,5-dihydrofuro[3,2-c]pyridin-4(2H)-ones. The reaction proceeds diastereoselectively with the formation of trans-isomers and represents a cascade process involving the Knoevenagel condensation, the carbo-Michael reaction, and intramolecular nucleophilic substitution.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a58927a99fb57406daa6b5f8b7330cbc https://doi.org/10.1007/s10593-020-02832-z Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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