ChemInform Abstract: Synthesis and anti-Mycobacterial Activity of (E)-N′-(Monosubstituted-benzylidene)isonicotinohydrazide Derivatives

Autor:	Maria C.S. Lourenço, Maria das Graças Henriques, Monica Amado Peralta, Marcelle de Lima Ferreira, Marcus Vinícius Nora de Souza, Thatyana R. A. Vasconcelos
Rok vydání:	2008
Předmět:	biology Chemistry Stereochemistry Isoniazid General Medicine biology.organism_classification In vitro Alamar blue Mycobacterium tuberculosis Minimum inhibitory concentration Anti mycobacterial medicine Antibacterial activity Rifampicin medicine.drug
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200842128
Popis:	A series of 22 (E)-N'-(monosubstituted-benzylidene)isonicotinohydrazide derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in mug/mL. Compounds 2f, 2g, 2j, 2k and 2q exhibited a significant activity (0.31-0.62 microg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new lead compounds in the fight against multi-drug resistant tuberculosis.
Databáze:	OpenAIRE
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