Formulation and Evaluation of Rosuvastatin Immediate Release Tablets 10 Mg
| Autor: | Abinash Chandro Sarker, Mohammad Mosleh Uddin, Chand Sultana, Md. Anwarul Haque, Sumon Kumar Dutta, Netish Kumar Kundo, Md. Nurul Islam |
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| Rok vydání: | 2016 |
| Předmět: |
Drug
Chemistry media_common.quotation_subject nutritional and metabolic diseases Pharmacology 030226 pharmacology & pharmacy Bioavailability 03 medical and health sciences Rosuvastatin Calcium Granulation 0302 clinical medicine medicine Sodium Starch Glycolate Rosuvastatin Immediate release Patient compliance 030217 neurology & neurosurgery medicine.drug media_common |
| Zdroj: | IOSR Journal of Pharmacy and Biological Sciences. 11:01-05 |
| ISSN: | 2278-3008 2319-7676 |
| DOI: | 10.9790/3008-1105030105 |
| Popis: | Rosuvastatin is a member of the drug class statins, used to treat high cholesterol and to prevent cardiovascular disease. It comes under class II of Biopharmaceutical Classification System. The objective of present study is to develop Rosuvastatin immediate release tablets 10 mg using different types of superdisintegrants to enhance the disintegration time and dissolution of Rosuvastatin calcium to improve bioavailability of the drug. In the present study immediate release formulation of Rosuvastatin calcium was prepared by wet granulation method that are cost effective. Different formulations were made by using various concentrations of superdisintegrants such as Crospovidone, Sodium Starch Glycolate and Kyron T-314 (Polacrillin Potassium). The Prepared formulations were evaluated for the physical characteristics, in vitro dissolution and stability at 40°C/ 75% RH for six months. Among all the formulations F2 (containing 4.5% of super disintegrants i.e., crospovidone) was considered to be the best formulation, which releases up to 102.4% drug in 30 minutes. From this study we can conclude that, formulated tablets of Rosuvastatin containing crospovidone are better and effective than conventional tablets to meet patient compliance. |
| Databáze: | OpenAIRE |
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