| Autor: |
Ruth E. Dayhoff, K.E. Marks, Robert S. Ledley, A.C. Breuer, Alden W. Dudley |
| Rok vydání: |
2005 |
| Předmět: |
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| Zdroj: |
The Seventh Annual Symposium on Computer Applications in Medical Care, 1983. Proceedings.. |
| DOI: |
10.1109/scamc.1983.764763 |
| Popis: |
The mechanism of nerve cell transport, the process by which substances made in a nerve cell body are moved long distances along a nerve cell process or axon, remains a major unsolved problem in biomedicine. Using a light microscope with the recently developed video hanced contrast method with interference contrast optics, it is possible to detect small subecllular structures down to 25 nm in size, and organelle traffic within axons can be visualized. Up until now, relatively few direct measurements on the transport of these structures have been made. The TEXAC whole-picture image analysis computer has been used to develop an automatic neural particle tracking system. This automated computer image processing and tracking method can be used to analyze the motions of directly observed intra-axonal organelles. Quantitative analysis of this phenomenon with high spacial and temporal resolution may yield clues to the molecular transport mechanism. It may also yield further insight into several lethal human neurologic disorders such as Amyotrophic Lateral Sclerosis and Alzheimer's disease, enigmatic disorders in which a nerve cell transport abnormality has been implicated. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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