Insight on thermal behaviour of new complexes of Ni(II), Cu(II) and Zn(II) with a bismacrocyclic ligand developed as biologically active species
| Autor: | Dana Marinescu, Rodica Olar, Maria-Nicoleta Grecu, Veronica Lazar, Mihaela Badea, Cristina Bucur, Mariana Carmen Chifiriuc, Coralia Bleotu |
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| Rok vydání: | 2016 |
| Předmět: |
Thermogravimetric analysis
010405 organic chemistry Chemistry Ligand Inorganic chemistry Formaldehyde 010402 general chemistry Condensed Matter Physics 01 natural sciences Magnetic susceptibility 0104 chemical sciences law.invention Metal chemistry.chemical_compound Octahedron law visual_art visual_art.visual_art_medium Macrocyclic ligand Physical and Theoretical Chemistry Electron paramagnetic resonance Nuclear chemistry |
| Zdroj: | Journal of Thermal Analysis and Calorimetry. 127:487-497 |
| ISSN: | 1588-2926 1388-6150 |
| Popis: | A multi-component reaction involving metal ion, amines and formaldehyde has been used for a series of decaaza bismacrocyclic complexes M2L(CH3COO)4·nH2O [(1) M: Ni, n = 2.5; (2) M:Cu, n = 1; (3) M:Zn, n = 10; L:1,3-bis(N,N-1,3,6,9,12-pentaazacyclotridecane)-benzene] preparation. Elemental analyses, ESI-MS, IR, UV–Vis–NIR, NMR and EPR spectra, magnetic susceptibility at room temperature, molar conductivities, as well as thermogravimetric analysis, provided data concerning complexes features. The macrocyclic ligand behaves as bischelate, resulting in either a square planar or an octahedral stereochemistry. The in vitro screening of the antimicrobial activity was performed against both reference and clinical isolates multi-drug-resistant strains. The overall antimicrobial potency of complexes was enhanced in comparison with the free ligand, against both planktonic and biofilm-embedded pathogenic strains. Complexes exhibit no cytotoxicity on the HCT 8 tumour cells. Thermogravimetric curves (TG, DTG and DTA) evidenced in air processes as water elimination, acetate into carbonate transformation as well as oxidative degradation of the bismacrocyclic ligand. The powder X-ray diffraction data indicate MO (M: Ni, Cu, Zn) as final product. |
| Databáze: | OpenAIRE |
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