Chitosan-Based Hydrogel Composition with Megosine

Autor:	E. M. Sultanova, Sh. I. Salikhov, M. Zh. Oripova, Yu. I. Oshchepkova
Rok vydání:	2020
Předmět:	Pharmacology Drug 010405 organic chemistry media_common.quotation_subject Kinetics technology industry and agriculture Liquid phase macromolecular substances complex mixtures 01 natural sciences 0104 chemical sciences Chitosan 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Chemical engineering chemistry Prolonged release Polymer solution Drug Discovery Self-healing hydrogels Composition (visual arts) media_common
Zdroj:	Pharmaceutical Chemistry Journal. 54:514-517
ISSN:	1573-9031 0091-150X
Popis:	Chitosan hydrogels containing the antiviral drug megosine were prepared. The conditions (concentrations of polymer solution, cross-linking agent, and drug substance) were selected so that the hydrogel could be formed without separating the liquid phase. The possibility for prolonged release of megosine from the developed chitosan hydrogel was demonstrated. Megosine in the hydrogels administered vaginally did not penetrate into blood and organs. The release kinetics of megosine from the chitosan hydrogels were studied and showed 59% release of megosine from the hydrogel in 7 h.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a56640378df999ceb1a094bc33702ac1 https://doi.org/10.1007/s11094-020-02230-x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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