The Pictet-Spengler reaction in the synthesis of condensed benzodiazepines 1. synthesis of 6,11,12,14-tetrahydrobenzo-[4,5][1,2]diazepino[7,1-b]quinazolin-14-ones

Autor:	A. I. Khizhan, A. S. Tolkunov, S. L. Bogza
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Pictet–Spengler reaction chemistry Organic Chemistry Trifluoroacetic acid Organic chemistry Hydrochloric acid Combinatorial chemistry
Zdroj:	Chemistry of Heterocyclic Compounds. 46:592-599
ISSN:	1573-8353 0009-3122
DOI:	10.1007/s10593-010-0550-x
Popis:	A new strategy is proposed for the synthesis of the seven-membered heterocyclic skeleton of tetrahydro[4,5][1,2]diazepino[7,1-b]quinazolin-14-ones based on the Pictet-Spengler reaction of 3-amino-2-(3,4-dimethoxybenzyl)quinazolin-4(3H)-one with aromatic aldehydes and paraform in acid media.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a562d130c37fc6176c8151784c374856 https://doi.org/10.1007/s10593-010-0550-x Zobrazit plný text záznamu Plný text ve formátu PDF