Gestational diabetes –Does it influence the thyroid hormone levels of the foetus in utero?
| Autor: | Joseph Paul Thyparambil, B Sulekha, Deepti G N, Sreekumari S, Geetha A |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | International Journal of Clinical Biochemistry and Research. 6:579-583 |
| ISSN: | 2394-6377 2394-6369 |
| DOI: | 10.18231/j.ijcbr.2019.120 |
| Popis: | Introduction: Babies born of mothers with gestational diabetes tend to develop obesity and diabetes in later life. This occurs in spite of good control of gestational diabetes. It was decided to study whether the maternal hyperglycemia produces any alteration in thyroid function of the foetus which could account for the development of insulin resistance and obesity in later years. The present study was done to find the level of thyroid hormones in the cord blood of infants of mothers with gestational diabetes. Materials and Methods: The study included 32 pregnant women who were suffering from gestational diabetes mellitus and their newborn babies. The severity of maternal diabetes was assessed by the fasting and postprandial blood sugar levels and the glycated haemoglobin levels. The glycated haemoglobin was estimated during the third trimester of pregnancy. The thyroid hormone levels and blood sugar was estimated in cord blood. The birth weight of the baby was also noted. Result: In our study, the serum T3 levels in cord blood was very much increased as compared to the normal range The cord blood T3 levels also showed a statistically significant positive correlation with the maternal postprandial glucose levels and the glycated haemoglobin levels. The T3 levels in cord blood of babies were much higher in those mothers who required insulin than the mothers who were controlled with diet alone. Conclusion: The increased T3 levels in cord blood may be an indicator of the hyperglycemia to which the foetus is exposed during intrauterine life. Keywords: Gestational diabetes mellitus, Cord blood thyroid hormone levels, Deiodinase enzyme, Glycated haemoglobin TSH (thyroid stimulating hormone), T4(tetraiodothyronine, T3 (tri iodothyronine), Glucose challenge test, Oral glucose tolerance test. |
| Databáze: | OpenAIRE |
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