| Autor: |
Hui Wang, Yun-Peng Zhao, Xing Gu, Peng Qi, Can-ping Ruan, Feiguo Zhou, Chunfang Gao |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Colorectal Disease. 12:1153-1158 |
| ISSN: |
1462-8910 |
| DOI: |
10.1111/j.1463-1318.2009.02079.x |
| Popis: |
Aim Colorectal cancer is common, accounting for nearly 10% of all cancers. Transforming growth factor-β1 (TGF-β1) is a pleiotropic cytokine that has been implicated in the pathogenesis of colorectal neoplasia. The most studied −509C>T polymorphism of TGF-β1 gene has been associated with various kinds of cancer. This study investigated the association between this genetic variant and the risk and/or progression of colorectal cancer. Method A case–control study was carried out of 150 colorectal cancer cases and 503 healthy controls. DNA was extracted from blood cell nuclear materials, and −509C>T polymorphism in the TGF-β1 gene promoter was genotyped by polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP). Colorectal cancer tissues (n = 70) were obtained from the studied cases for measurement of TGF-β1 mRNA expression levels. We also assessed the plasma TGF-β1 levels of cases (n = 88) and healthy subjects (n = 120). Results The TGF-β1 producer genotype, −509TT, was not associated with an increased risk of colorectal cancer compared with other genotypes. Colorectal cancer patients especially those with a more aggressive disease behaviour were more frequently associated with C allele. Conclusion The results suggest that TGF-β1 −509C>T polymorphism is not associated with either an increased risk or progression of colorectal cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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