Ascorbic acid supplementation reduces oxidative stress and platelet biochemical function in type 2 diabetic patients. Relevance of ascorbic acid dosage and formulation
| Autor: | Sante D. Pierdomenico, Domenico Lapenna, Franco Cuccurullo, Giuliano Ciofani, Chiara Cuccurullo |
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| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Nutrition and Dietetics Antioxidant business.industry Endocrinology Diabetes and Metabolism Glutathione peroxidase medicine.medical_treatment medicine.disease_cause Ascorbic acid Placebo Lipid peroxidation chemistry.chemical_compound Endocrinology chemistry Internal medicine Medicine Lipoprotein oxidation Platelet activation business Oxidative stress |
| Zdroj: | e-SPEN Journal. 7:e245-e248 |
| ISSN: | 2212-8263 |
| DOI: | 10.1016/j.clnme.2012.09.006 |
| Popis: | Summary Background & aims We investigated the effects of twice daily oral supplementation with different ascorbic acid (AA) dosages and formulations on oxidative stress status and platelet biochemical function in type 2 diabetic patients (T2DP). Methods Ten T2DP were supplemented with 250 mg/day liquid AA (liq-AA), 10 T2DP with 1,000 mg/day liq-AA and 10 T2DP with placebo for 4 weeks; after suspension of liq-AA supplementation, the 250 mg/day liq-AA and placebo groups were switched to, respectively, supplementation with placebo and 1,000 mg/day chewable AA for further 4 weeks. Plasma AA (P-AA), LDL and erythrocyte lipoperoxides, erythrocyte glutathione peroxidase (E-GSH-Px1) activity and platelet lipoperoxides generated during thrombin-stimulated aggregation were assessed before and after the supplementation periods. Results Supplementation with 1,000 mg/day liq-AA was significantly more effective than supplementation with 1,000 mg/day chewable AA in increasing P-AA concentration, i.e. by about 93% compared to about 62%, as well as in reducing LDL, erythrocyte and platelet lipoperoxide levels and in augmenting E-GSH-Px1 activity; supplementation with 250 mg/day liq-AA increased only by about 28% plasma AA concentration and was ineffective. Conclusions Supplementation with 1,000 mg/day liq-AA is most effective in reducing oxidative stress status and platelet biochemical function in T2DP. |
| Databáze: | OpenAIRE |
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