Randomized trial of partial zona dissection for male infertility
| Autor: | John J. Koval, Jeffrey A. Nisker, Ian S. Tummon, Susan A.J. Daniel, Patricia M. Squires, Robert E. Gore-Langton, Mansour Alsalili, A. Albert Yuzpe, James S.B. Martin, Brian R. Kaplan |
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| Rok vydání: | 1995 |
| Předmět: |
Gynecology
endocrine system medicine.medical_specialty Pregnancy biology urogenital system business.industry Zona Reproductive medicine Obstetrics and Gynecology biology.organism_classification Insemination medicine.disease Polyspermy Male infertility medicine.anatomical_structure Human fertilization Reproductive Medicine embryonic structures Medicine business Zona pellucida reproductive and urinary physiology |
| Zdroj: | Fertility and Sterility. 63:842-848 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(16)57491-3 |
| Popis: | Objectives To compare IVF rates using partial zona dissection versus zona intact insemination in couples with male infertility. To analyze pregnancy rates relative to sperm characteristics, fertilization rates, and treatment. Design Randomized prospective comparison of fertilization in sibling oocytes. Transfer of the three best quality embryos from one or both treatments. Setting Department of Gynaecology and Reproductive Medicine, University Hospital, London, Ontario, Canada. Participants Thirty-two couples undergoing IVF with a principal diagnosis of male infertility. Intervention: Treatment with partial zona dissection. Main Outcome Measures Fertilization and pregnancy. Results Fertilization rates were 26% and 9% after partial zona dissection and IVF, respectively. Polyspermy was Conclusion Partial zona dissection was associated with minimal polyspermic fertilization and higher normal fertilization rates than sibling oocytes treated by modified IVF. Pregnancy occurred only after transfer of embryos from partial zona dissection or combined partial zona dissection and IVF. |
| Databáze: | OpenAIRE |
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