ChemInform Abstract: Determination of the Absolute Configuration of Chiral Secondary Alcohols; New Advances Using 13C and 2D NMR Spectroscopy

Autor:	Tõnis Pehk, Anne Paju, B. C. Borer, E. Lippmaa, Margus Lopp, Richard J. K. Taylor
Rok vydání:	2010
Předmět:	Chemistry Chemical shift Absolute configuration Diastereomer Physical chemistry General Medicine Spectroscopy Two-dimensional nuclear magnetic resonance spectroscopy
Zdroj:	ChemInform. 24
ISSN:	0931-7597
DOI:	10.1002/chin.199347039
Popis:	The use of 1 H- 13 C and 1 H- 1 H 2D COSY correlation experiments substantially enhances the potential of the NMR procedure for determining the absolute configuration of chiral secondary alcohols via their diastereomeric MPA and/or MTPA esters. Phenyl ring current effects are observed over remarkably long distances and comparable effects are seen for both 13 C and 1 H chemical shifts. The use of 13 C chemical shifts to aid configurational assignment is particularly valuable.
Databáze:	OpenAIRE
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