Synthesis of mono- and di-sialophospholipids via the H-phosphonate approach

Autor:	Harold J Jennings, Hongbin Yan
Rok vydání:	2006
Předmět:	Stereochemistry Polysialic acid Organic Chemistry Phospholipid Ether General Chemistry Phosphonate Catalysis MENINGOCOCCAL POLYSACCHARIDE Sialic acid chemistry.chemical_compound Residue (chemistry) Glycolipid chemistry
Zdroj:	Canadian Journal of Chemistry. 84:540-545
ISSN:	1480-3291 0008-4042
DOI:	10.1139/v06-031
Popis:	To overcome their inherent instability, stable modified mono- and di-sialophospholipids of the group C meningococcal polysaccharide were synthesized. Stability was achieved by introducing a spacer between the sialic acid residue and the phospholipid component, and by replacing the native ester linkages to the lipid by ether linkages. Mono- and di-hydroxylethylenesialosides were coupled to phosphoglyceroldietherlipid using H-phosphonate chemistry to give the anomerically pure sialophospholipids in good yields.Key words: polysialic acid, glycolipid, H-phosphonate, meningococcus.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a53478e07fee168d6b88c08108c93199 https://doi.org/10.1139/v06-031 Zobrazit plný text záznamu Plný text ve formátu PDF