Inflamación en la hernia del disco intervertebral
| Autor: | Jose Antonio Vega-Alvarez, Tatiana Cosamalón-Gan, José García-Cosamalón, Vega Villar-Suárez, Iván Cosamalón-Gan, Giancarlo Mattos-Piaggio |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Nerve root business.industry Inflammation Intervertebral disc herniation medicine.disease_cause Pathophysiology 03 medical and health sciences 0302 clinical medicine Lumbar medicine Immunohistochemistry Surgery Tumor necrosis factor alpha Neurology (clinical) Irritation medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Neurocirugía. 32:21-35 |
| ISSN: | 1130-1473 |
| DOI: | 10.1016/j.neucir.2020.01.001 |
| Popis: | Up until fairly recently, it was thought that sciatic pain in the lumbar herniated disc was caused by compression on the nerve root. However, the lumbar herniated disc shows mixed pictures which are difficult to explain by simple mechanical compromise. In recent years various immunology, immunohistochemistry and molecular biology studies have shown that the herniated tissue is not an inert material, but rather it Is biologically very active with the capability of expressing a series of inflammatory mediators: cytokines such as interleukin-1, interleukin-6, interleuquin-8 and tumor necrosis factor being the ones which stand out. The inflammation is not only induced by the chemical irritation of the bioactive substances released by the nucleus pulposus but also by an autoimmune response against itself. Thus, in addition to the mechanical factor, the biomechanical mediation plays an important role in the pathophysiology of sciatic pain and of radiculopathy. Through a review of a wide range of literature, we researched the cellular molecular mediators involved in this inflammatory process around the lumbar herniated disc and its involvement in sciatic pain. |
| Databáze: | OpenAIRE |
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