Acute myeloid leukemia associated with a novel GATA2 mutation: a case report and the importance to identify GATA2 haplodeficiency
| Autor: | Francianne Gomes Andrade, Fernando Sellos, Maria S. Pombo-de-Oliveira, Sheila C. Soares‐Lima, Daniela P Mendes-de-Almeida, Patrícia G Moura, Filipe V. dos Santos-Bueno |
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| Rok vydání: | 2020 |
| Předmět: |
Zinc finger
Cancer Research Myeloid GATA2 Myeloid leukemia Hematology Biology medicine.disease 03 medical and health sciences Leukemia Haematopoiesis 0302 clinical medicine medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Mutation (genetic algorithm) medicine Cancer research Transcription factor 030215 immunology |
| Zdroj: | Leukemia & Lymphoma. 61:3010-3013 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.1080/10428194.2020.1795163 |
| Popis: | GATA2 encodes a pioneer transcription factor that harbors two zinc fingers. It is a master regulator of hematopoiesis and is pivotal for self-maintenance and differentiation [1]. Heterozygous germl... |
| Databáze: | OpenAIRE |
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