Ubiquitin ligase Wwp1 gene deletion attenuates diastolic dysfunction in pressure-overload hypertrophy
| Autor: | Yimu Lai, Heather Doviak, Valerie K. Laney, Lisa A. Freeburg, Kia N. Zellars, Laura B. Snyder, Francis G. Spinale, Lydia E. Matesic, Amber Moore |
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| Rok vydání: | 2021 |
| Předmět: |
Pressure overload
medicine.medical_specialty Ejection fraction biology Physiology business.industry Diastole medicine.disease Ubiquitin ligase Muscle hypertrophy Extracellular matrix Physiology (medical) Internal medicine Heart failure biology.protein Cardiology Medicine Cardiology and Cardiovascular Medicine business Ventricular remodeling |
| Zdroj: | American Journal of Physiology-Heart and Circulatory Physiology. 321:H976-H984 |
| ISSN: | 1522-1539 0363-6135 |
| Popis: | Heart failure with a preserved left ventricular (LV) ejection fraction (HFpEF) often arises from a prolonged LV pressure overload (LVPO) and is accompanied by abnormal extracellular matrix (ECM) accumulation. It is now recognized that the ECM is a dynamic entity that is regulated at multiple post-transcriptional levels, including the E3 ubiquitin ligases, such as WWP1. In the present study, WWP1 deletion in the context of an LVPO stimulus reduced functional indices of HFpEF progression and determinants of ECM remodeling. Understanding and targeting the ubiquitin ligases in the context of HFpEF forms an important research direction. |
| Databáze: | OpenAIRE |
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