| Autor: |
Adriana Gruppi, Ian A. Cockburn, María Cecilia Ramello, Rodriguez Eva, Jimena Tosello Boari, Pablo F. Canete, Carolina L. Montes, Melisa Gorosito Serran, Facundo Fiocca Vernengo, Yeping Cai, Cristian Gabriel Beccaria, Laura Almada, Carola G. Vinuesa, Alegre, Zuniga I E, Wehrens E |
| Rok vydání: |
2020 |
| Předmět: |
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| DOI: |
10.1101/2020.06.10.142067 |
| Popis: |
During infections with protozoan parasites or virus, T cell immunosuppression is generated simultaneously with a high B cell activation. Here, we show that in T. cruzi infection, all plasmablasts detected had higher surface expression of PD-L1, than other mononuclear cells. PD-L1hi plasmablasts were induced in vivo in an antigen-specific manner and required help from Bcl-6+CD4+T cells. PD-L1hi expression was not a characteristic of all antibody-secreting cells since plasma cells found during the chronic phase of infection express PD-L1 but at lower levels. PD-L1hi plasmablasts were also present in mice infected with Plasmodium or with lymphocytic choriomeningitis virus, but not in mice with autoimmune disorders or immunized with T cell-dependent antigens. PD-L1hi plasmablasts suppressed T cell response, via PD-L1, in vitro and in vivo. Thus, this study reveals that extrafollicular PD-L1hi plasmablasts, which precede the germinal center (CG) response, are a suppressive population in infections that may influence T cell response.Brief summaryPathogens develop different strategies to settle in the host. We identified a plasmablats population induced by pathogens in acute infections which suppress T cell response. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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