Homoisoflavonoids from the tuberous roots of Ophiopogon japonicus with their cytotoxic activities
| Autor: | Bo Song, Ji-Feng Xu, Li Li, Ji-Kai Sun, Ying Chen, Jin-Xuan Chai, Wei Dong, Li-Na Guo, Chun-Jing Zhang, Xiaoli Wang |
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| Rok vydání: | 2021 |
| Předmět: |
biology
010405 organic chemistry Chemistry Ophiopogon japonicus Absolute configuration Plant Science biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry Cell culture Cytotoxic T cell Agronomy and Crop Science IC50 Human cancer Biotechnology |
| Zdroj: | Phytochemistry Letters. 44:31-34 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2021.05.002 |
| Popis: | Two new homosioflavonoids, ophiopogonanone I (1) and methylophiopogonanone C (2) were isolated from the tuberous roots of Ophiopogon japonicus. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configuration of compounds 1 and 2 were assigned on the basis of CD method. In addition, compounds 1–2 were tested for their cytotoxic activities against HL-60, SMMC-7721, and MCF-7 human cancer cell lines, and compound 2 showed significant cytotoxic activity against HL-60 cell line with IC50 value of 14.42 μM. |
| Databáze: | OpenAIRE |
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