High Gentamicin Trough Concentrations in Neonates of Less than 28 Weeks Gestational Age
| Autor: | Ralph J. Wynn, Barbara J. Zarowitz, Stanley J. Szefler, Sharon Buckwald |
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| Rok vydání: | 1982 |
| Předmět: | |
| Zdroj: | Developmental Pharmacology and Therapeutics. 5:68-75 |
| ISSN: | 2504-2505 0379-8305 |
| Popis: | 77 newborns, ranging from 25.5 to 43 weeks gestational age (GA) and receiving gentamicin, were studied prospectively over 4 months. Peak and trough serum concentrations were obtained on days 1, 3, and 5 of therapy. Gentamicin, 2.5 mg/kg/dose, was given at intervals according to GA. 63% of newborns of less than 28 weeks on doses of gentamicin of 2.5 mg/kg every 24 h (q24h), 75% of less than 28 weeks on gentamicin q18h, 90% of newborns of 23-34 weeks (on q18h), and 82% of those of greater than 34 weeks GA (on q12h) had serum gentamicin trough concentrations less than or equal to 2.0 micrograms/ml on day 1. By day 3, 5/5 newborns of less than 28 weeks (q18h) had trough concentrations greater than 2.0 micrograms/ml, whereas only 20% of those on the q24h regimen had high trough concentrations (p less than 0.05). Possible risk factors associated with altered gentamicin disposition in neonates are discussed. |
| Databáze: | OpenAIRE |
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