Age-related changes in the dopaminergic system of rat striatum

Autor:	G. I. Kovalev, T A Voronina, V. S. Kudrin, R R Gaĭntdinov, Evgeny A. Budygin
Rok vydání:	1993
Předmět:	medicine.medical_specialty Chemistry Dopaminergic General Medicine Striatum General Biochemistry Genetics and Molecular Biology Rat striatum Basal (phylogenetics) Neurochemical Endocrinology nervous system Dopamine Internal medicine Age related Basal metabolic rate medicine medicine.drug
Zdroj:	Bulletin of Experimental Biology and Medicine. 115:331-333
ISSN:	1573-8221 0007-4888
Popis:	The dopaminergic neurochemical parameters of the adult (3 months) rat's striata in comparison with those of aged (26 months) ones were studied using HPLC/ED method. It was shown that Dopamine (DA) and its intracellular metabolite DOPAC content increase in striatal homogenates of aged rats up to 153 and 165%, accordingly. The level of other metabolite--HVA, as well as intensity of basal DA efflux from perfused isolated striata decreased to 77 and 45%, respectively. The high negative correlation (r = -0.90; p 0.05). The suggestion concerning the aging--related changes of the interactions within striatal DA-ergic system is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a51bda04b3420be39afd907c080612eb https://doi.org/10.1007/bf00836430 Zobrazit plný text záznamu Full text from SpringerLink