Stimulatory and inhibitory (biphasic) motor response of ovine duodenum to cholecystokinin-octapeptide and cerulein
| Autor: | K. W. Romański |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Physiology Chemistry digestive oral and skin physiology Inhibitory postsynaptic potential digestive system medicine.anatomical_structure Endocrinology Physiology (medical) Internal medicine Duodenal bulb medicine Duodenum Cholecystokinin Octapeptide Ecology Evolution Behavior and Systematics Ceruletide Migrating motor complex Cholecystokinin Hormone |
| Zdroj: | Biological Rhythm Research. 41:313-323 |
| ISSN: | 1744-4179 0929-1016 |
| DOI: | 10.1080/09291010903411450 |
| Popis: | Cholecystokinin (CCK) appears to induce profound alterations in intestinal motility but in ruminants the question has not been entirely explored. Thus this study aimed to examine the precise effects of CCK-octapeptide (CCK-OP) and its amphibian analogue, cerulein, on duodenal motor activity in non-fasted rams in chronic experiments. Six adult rams underwent implantation of a strain gauge force transducer to the duodenal wall, and – additionally – the bipolar platinum electrodes to the duodenal bulb, distal duodenum, just near the strain gauge force transducer, and to the proximal jejunum. During ongoing motor recordings, 0.15 M NaCl or CCK peptides were administered intravenously. Slow injections of CCK-OP at doses of 20 (over 30 s), 200 (over 30 or 60 s), and 2000 (over 30, 60, or 120 s) ng/kg of body weight and slow injections of cerulein at doses 1, 10, or 100 ng/kg (given over the same periods) were each performed in the course of duodenal phases 1, 2a, or 2b of the migrating motor complex (MMC), i.e.... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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