M2071 Innate Immune Defects in IRGM1, TLR2, and NOD2 Contribute to Crohn's Disease Risk and Severity in Ashkenazi Jews

Autor:	Asher Kornbluth, Adele A. Mitchell, Peter H. Rubin, Joel J. Bauer, Monica Erazo, Simon Lichtiger, Maria T. Abreu, Sari Feldman, Barry W. Jaffin, Jane Im, Juan L. Mendoza, Daniel H. Present, Melissa Marotta, James Aisenberg, Lloyd Mayer, Thomas A. Ullman, Eric S. Goldstein, Anthony Weiss, Kenneth M. Miller, Ruth Ann Denchy
Rok vydání:	2008
Předmět:	Genetics Crohn's disease Innate immune system Hepatology business.industry Gastroenterology medicine.disease Phenotype Ashkenazi jews TLR2 NOD2 Immunology medicine Gene polymorphism Allele business
Zdroj:	Gastroenterology. 134:A-463
ISSN:	0016-5085
DOI:	10.1016/s0016-5085(08)62164-2
Popis:	ively). Furthermore, IL-17A -197A allele was significantly associated with chronic relapsing phenotype (OR, 2.36; 95%CI, 1.34-4.15; p=0.0028) and steroid-dependent cases (OR, 2.14; 95%CI, 1.03-4.45; p=0.040), whereas IL-17F 7488T allele was associated with chronic continuous phenotype (OR, 2.71; 95%CI, 1.13-6.49; p=0.025). [Conclusion] Our results provided the first evidence that IL-17A and -17F gene polymorphism was significantly associated with the development of UC. IL-17A -197A and -17F 7844T alleles may influence the susceptibility to and pathophysiological features of UC independently.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a515be529448a747552e1f3a1bbd274f https://doi.org/10.1016/s0016-5085(08)62164-2 Zobrazit plný text záznamu