| Autor: |
Bruno Gualano, Ítalo R. Lemes, Rafael Silva, Ana Jessica Pinto, Bruna Mazzolani, Fabiana I. Smaira, Sofia M. Sieczkowska, Nadia Aikawa, Sandra Pasoto, Ana C. Medeiros-Ribeiro, Carla Saad, Emily Neves, Clovis Silva, Paul Swinton, Pedro Hallal, Hamilton Roschel, Eloisa Bonfa |
| Rok vydání: |
2021 |
| Popis: |
This study aimed to investigate the association between physical activity and persistent anti-SARS-CoV-2 antibodies 6 months after two-dose schedule of CoronaVac in autoimmune rheumatic diseases (ARD) patients. This was a prospective cohort study within an open-label, single-arm, phase 4 vaccination trial (clinicaltrials.gov #NCT04754698), conducted at a tertiary referral hospital in Sao Paulo, Brazil. ARD patients aged ≥18 underwent a two-dose schedule of CoronaVac (Sinovac Life Sciences, China). Persistent immunogenicity 6 months after the full-course vaccination was assessed using seroconversion rates of total anti-SARS-CoV-2 S1/S2 IgG, geometric mean titers of anti-S1/S2 IgG (GMT), and frequency of positive neutralizing antibodies (NAb). Physical activity was assessed trough questionnaire (active being defined as ≥150 min/week of moderate-to-vigorous physical activity). Physically active (n=421) and inactive (n=327) ARD patients were similar for most characteristics; however, active patients were significantly younger (ppppppp |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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