Differential Effect of the DopamineD3Agonist (±)-7-Hydroxy-2-(N,N-di-n-propylamino) Tetralin (7-OH-DPAT) on Motor Activity between Adult Wistar and Sprague-Dawley Rats after a Neonatal Ventral Hippocampus Lesion
| Autor: | Sergio Zamudio, Sonia Guzmán-Velázquez, Linda Garcés-Ramírez, Fidel de la Cruz, Gonzalo Flores |
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| Rok vydání: | 2011 |
| Předmět: |
Agonist
7-OH-DPAT medicine.medical_specialty Pathology medicine.drug_class Hippocampus Hippocampal formation medicine.disease Biochemistry Lesion chemistry.chemical_compound Endocrinology chemistry Dopamine receptor D3 Schizophrenia Internal medicine Drug Discovery medicine Molecular Medicine medicine.symptom Receptor |
| Zdroj: | International Journal of Medicinal Chemistry. 2011:1-8 |
| ISSN: | 2090-2077 2090-2069 |
| DOI: | 10.1155/2011/648960 |
| Popis: | The neonatal ventral hippocampal lesion (nVHL) has been widely used as an animal model for schizophrenia. Rats with an nVHL show several delayed behavioral alterations that mimic some symptoms of schizophrenia. Sprague-Dawley (SD) rats with an nVHL have a decrease in D3receptors in limbic areas, but the expression of D3receptors in Wistar (W) rats with an nVHL is unknown. The 7-Hydroxy-2-(N,N-di-n-propylamino) tetralin (7-OH-DPAT) has been reported as a D3-preferring agonist. Thus, we investigated the effect of (±)-7-OH-DPAT (0.25 mg/kg) on the motor activity in male adult W and SD rats after an nVHL. The 7-OH-DPAT caused a decrease in locomotion of W rats with an nVHL, but it did not change the locomotion of SD rats with this lesion. Our results suggest that the differential effect of 7-OH-DPAT between W and SD rats with an nVHL could be caused by a different expression of the D3receptors. These results may have implications for modeling interactions of genetic and environmental factors involved in schizophrenia. |
| Databáze: | OpenAIRE |
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