Laser fluorescence investigation of chlorin e6 pharmacokinetics

Autor:	Grigor Gyulkhandanyan, Asatour Lalaian, Vladimir A. Hovanessian
Rok vydání:	1996
Předmět:	Materials science Radiochemistry Analytical chemistry Spectrofluorometer Laser fluorescence Laser Fluorescence law.invention chemistry.chemical_compound Pigment Pharmacokinetics chemistry law visual_art Chlorin visual_art.visual_art_medium Luminescence
Zdroj:	SPIE Proceedings.
ISSN:	0277-786X
DOI:	10.1117/12.260784
Popis:	The pharmacokinetic behavior of chlorin e6 in different organs and tumor tissues of rats infected with Sarcoma-45 has been investigated with help of the fiber-optic spectrofluorometer at excitation by harmonics of YAG:Nd laser ((lambda) equals 355, 532 and 660 nm). The most intensive chlorine e6 fluorescence in tumor tissue was observed in 18 hours after pigment injection. The optimal time of fluorescence diagnosis has been determined (in 27 hours after pigment injection). The maximum of the tumor-to- normal tissue ratio of fluorescence was equal 10 at 666 nm. The rates of the accumulation and elimination of chlorin e6 in the skin, hypodermic tissues and tumors of rats were determined in vivo.© (1996) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Databáze:	OpenAIRE
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