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BackgroundThe 2019 coronavirus disease (COVID-19) is a global public health emergency. So far, only a limited number of studies have investigated the impact of the pneumonia pandemic in COVID-19 on the mental health of parents having children with cancer. This study investigated the hope, depression, anxiety, and relevant influencing factors among parents of retinoblastoma patients during the pneumonia epidemic in COVID-19.MethodsA total of 317 parents having children with retinoblastoma admitted to the Ninth People’s Hospital affiliated with the Shanghai Jiao Tong University, School of Medicine, and Qilu Children’s Hospital of Shandong University were investigated by cross-sectional investigation and convenient sampling. The survey tools included a Demographic Questionnaire, Herth Hope Index (HHI), The Generalized Anxiety Disorder (GAD-7), and The Patient Health Questionnaires (PHQ)-2. ResultsThe hope level score of the parents of retinoblastoma patients was (35.36 ±4.42), which was at the medium level. The highest dimension of the hope score was to take positive action (12.07± 1.57), and the lowest dimension was to maintain a close relationship with others (11.50± 1.64). The incidence rates of anxiety and depression were 41.32% (131/317) and 29.97% (95/317), respectively. Hope level was negatively correlated with anxiety and depression. Monoculus or binoculus disease, sleep quality, health status, having anxiety/depression or not, had a statistically significant effect on the research subjects' hope level (p |