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A 6-week experiment was conducted to evaluate the effect of a dietary herb extracts mixture (HEM) on growth performance, nutrient digestibility, blood characteristics, and fecal microbial shedding in weanling pigs. A total of 144 pigs [(Landrace × Yorkshire) × Duroc] (BW = 7.6 ± 0.6 kg; weaned at d 21) were randomly allocated to 4 treatments according to their BW and sex (9 replicates of 4 pigs per treatment). Treatments followed a 2 × 2 factorial design with 2 levels of HEM (0 or 250 mg kg− 1 diet) and apramycin (0 or 30 mg kg− 1 diet). During the first week, pigs fed HEM supplemented diets led to a lower (P |