Gram-scale synthesis and efficient purification of13C-labeled levoglucosan from13C glucose
| Autor: | Dave L. Thorn, Ryszard Michalczyk, Ruilian Wu, Caroline B. Hoyt, Lisa Alexander, L. A. 'Pete' Silks |
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| Rok vydání: | 2012 |
| Předmět: |
Substitution reaction
Chromatography Anomer Silica gel Levoglucosan Organic Chemistry One-Step Biochemistry Chloride Analytical Chemistry chemistry.chemical_compound chemistry Yield (chemistry) Drug Discovery medicine Organic chemistry Radiology Nuclear Medicine and imaging Spectroscopy medicine.drug Gram |
| Zdroj: | Journal of Labelled Compounds and Radiopharmaceuticals. 56:27-29 |
| ISSN: | 0362-4803 |
| DOI: | 10.1002/jlcr.2978 |
| Popis: | (13)C-Labeled levoglucosan has been synthesized and purified in good yield, and on the gram scale in one step from commercially available (13)C glucose. This one-step protocol uses 2-chloro-1,3-dimethylimidazolinium chloride that serves to selectively activate the anomeric carbon toward substitution reactions. The labeled glucose is then smoothly converted to the anhydroglucose. Purification is efficiently achieved on large scale by chromatography on silica gel. |
| Databáze: | OpenAIRE |
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