Steroid-induced impairment of glucose tolerance: Prevalence among pediatric patients on long-term steroid use in Nigeria
| Autor: | OM Ugege, T Oguonu, MaryAnn Ugochi Ibekwe, Ikechukwu Frank Ogbonna, Adaobi I. Bisi-Onyemaechi, Ugo N. Chikani, Carine de Beaufort, Lucy N Wainaina Mungai |
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| Rok vydání: | 2017 |
| Předmět: |
Budesonide
medicine.medical_specialty Pediatrics business.industry Endocrinology Diabetes and Metabolism medicine.medical_treatment 030204 cardiovascular system & hematology medicine.disease Steroid 03 medical and health sciences 0302 clinical medicine Steroid use Internal medicine Pediatrics Perinatology and Child Health Internal Medicine medicine 030212 general & internal medicine business Body mass index Nephrotic syndrome Glucocorticoid Fluticasone medicine.drug Asthma |
| Zdroj: | Pediatric Diabetes. 18:942-946 |
| ISSN: | 1399-543X |
| DOI: | 10.1111/pedi.12514 |
| Popis: | Introduction Glucocorticoid (referred to from here on as simply steroid) is used for effective treatment of various inflammatory disorders since its discovery in 1940s. However, these useful drugs cause important side effects, such as impairment of glucose tolerance. We sought to determine the prevalence of steroid-induced impairment of glucose tolerance in pediatric patients on long-term steroid use. Materials and Methods A cross-sectional, descriptive and hospital-based study. Consenting subjects who met the inclusion criteria were screened with random glucometer measurements repeated twice. An average of both readings obtained from the initial measurement of their random blood glucose (RBG) and a repeat during the next clinic visit was taken as the RBG. Results Hundred patients were studied, 66 males/34 females. Subjects with nephrotic syndrome were 61 while 39 had asthma. Mean age of 10.13 years (range: 0.5-18 years); mean body mass index (BMI): 18.2 kg/m2 (range: 6.6 to 26.30 kg/m2). The subjects with nephrotic syndrome were on oral prednisolone while the asthmatics were on inhaled fluticasone, budesonide and oral methylprednisolone. Mean (range) duration of steroid use was 9.74 (0.5-72) months. Mean (range) RBG was 3.49 (3.3-7.5) mmol/L. None of the subjects showed abnormal RBG. However, the RBG was further categorized into low, moderate and high normal RBG. A positive correlation between longer duration of steroid use as well as high doses of both oral and inhaled steroids, and high normal RBG existed (P = .015). No statistically significant relationship existed between body mass index (BMI) percentile and RBG (P = .437). Conclusion Low to moderate doses of oral and inhaled steroids should be used when indicated as they are associated with lesser risk of impairment of glucose tolerance in the pediatric population. |
| Databáze: | OpenAIRE |
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