Facile synthesis of fluoroalkylated quinolones using fluoroalk-2-ynoates as fluorinated building blocks

Autor:	Hui Zhang, Xiao Ding, Liping Song, Jun Wu, Jie Chen, Xuefei Tan, Weiguo Cao, Hongmei Deng, Weimin He, Hong C. Shen
Rok vydání:	2019
Předmět:	Inorganic Chemistry 010405 organic chemistry Isatoic anhydride Chemistry Organic Chemistry Environmental Chemistry Physical and Theoretical Chemistry 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Adduct
Zdroj:	Journal of Fluorine Chemistry. 220:54-60
ISSN:	0022-1139
DOI:	10.1016/j.jfluchem.2019.02.002
Popis:	In the presence of Na2CO3, a variety of fluoroalkylated quinolones were efficiently synthesized from isatins and fluoroalk-2-ynoates in good to excellent yields at room temperature. The reaction can proceed via two different ways with Michael adduct or isatoic anhydride as the key intermediate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a4e82cb5c1f2b594972e7f72039c1bfa https://doi.org/10.1016/j.jfluchem.2019.02.002 Zobrazit plný text záznamu Full Text from ScienceDirect