Carbamazepine-induced hypersensitivity pneumonitis in a patient with neuromyelitis optica: A case report

Autor:	Furqan Mohd. Akram Khan, Dhaval Dave, Shalesh Rohatgi, Satish Nirhale, Prajwal Rao, Pravin Naphade, V. V. Sravya Kotaru, Sahil Gupta, Advait Gupta, Prashant Dubey
Rok vydání:	2022
Předmět:	Pharmacology Physiology Physiology (medical)
Zdroj:	Indian Journal of Physiology and Pharmacology. 66:81-83
ISSN:	2582-2799 0019-5499
DOI:	10.25259/ijpp_282_2021
Popis:	A 36-year-old female with serum anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (NMOSD) on carbamazepine (CBZ) therapy for paroxysmal tonic spasms (PTS) developed Type 1 respiratory failure. High-resolution computed tomography chest showed diffuse ground-glass opacities in both lungs predominantly in bilateral perihilar region sparing subpleural regions and predominantly upper lobes with a smooth interlobular septal thickening. A transbronchial lung biopsy was consistent with hypersensitivity pneumonitis and following withdrawal of the CBZ and treatment with steroids her respiratory symptoms resolved. After stopping CBZ, PTS recurred, which was successfully treated with lacosamide. This is the first described biopsy-proven case of CBZ-induced hypersensitivity pneumonitis in the NMOSD patient.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::a4da1bd280f1f3d6115c69c7b2c16cdd https://doi.org/10.25259/ijpp_282_2021 Zobrazit plný text záznamu