456 PREMATURE ADRENARCHE: CLINICAL AND DIAGNOSTIC FEATURES
| Autor: | Janice L. Cockrell, P B Kaplowitz, Harold M. Maurer |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
medicine.medical_specialty
business.industry Adrenarche Serum concentration Gastroenterology Pubic hair Androgen secretion chemistry.chemical_compound Endocrinology Dehydroepiandrosterone sulfate medicine.anatomical_structure chemistry Internal medicine Pediatrics Perinatology and Child Health Etiology medicine Menarche Family history business |
| Zdroj: | Pediatric Research. 19:186A-186A |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-198504000-00486 |
| Popis: | Premature adrenarche (PA), or isolated development of pubic hair before age 8, is common in the Richmond area. We have compared the clinical findings, family history and serum concentrations of dehydroepiandrosterone sulfate (DHEA-S), in 21 new cases of PA seen in the past 2 yrs and in 17 control children. Since 17/21 of the PA patients were black females, black girls between 3 and 8 yrs were used as controls. The height age was on the average 7.5 mo greater than the chronological age in the PA patients, but was also greater (by 8.1 mo) in the control group. Twenty of 21 patients, but none of the controls, had a history of an adult-type axillary odor, which in 8 cases preceded the growth of hair by more than 3 months. There was a positive family history for PA in only 3 of 21 children with PA, and in 1 of 17 controls. The average age of maternal menarche was not significantly different for the PA and the control groups. Serum DHEA-S (Nichols Institute, Los Angeles, CA) was significantly higher in the PA children at all ages. For children < 6 yrs, PA= 49 ± 29 μg/dl (range 10 to 92) and control = 11 ± 8 μg/dl (range < 5 to 26), p < .001; for children 6–8 yrs, PA = 52 ± 23 μg/dl (range 19 to 110) and controls = 20 ± 16 μg/dl (range |
| Databáze: | OpenAIRE |
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