| Autor: |
Byeong Gyu Shin, H. Christian Hong, Sangwook Wu, Hyun Jong Kim, Abdennour Braka, Yang Je Cho, Shin Ae Park, Seok-Hyun Kim, Seung Won Chung, Eun Young Hong, Jayaraman Thangappan, Min Jeong Chun, Sunghoon Jang, Kwang Sung Kim |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
In addition to the traditional method of vaccine development, the mRNA coronavirus vaccine, which is attractive as a challenging vaccination, recently opened a new era in vaccinology. Here we describe the EG-COVID which is a novel liposome-based mRNA candidate vaccine that encodes the spike (S) protein of SARS-CoV-2 with 2P-3Q substitution in European variant. We developed the mRNA vaccine platform that can be lyophilized using liposome-based technology. Intramuscular injection of the EG-COVID elicited robust humoral and cellular immune response to SARS-CoV-2. Furthermore, sera obtained from mice successfully inhibited SARS-CoV-2 viral infection into Vero cells. We developed EG-COVID and found it to be effective based on in vitro data, and we plan to initiate a clinical trial soon. Since EG-COVID is a lyophilized mRNA vaccine that is convenient for transportation and storage, accessibility to vaccines will be significantly improved. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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