Synthesis, Crystal and Molecular Structure of Boc-Pro-ΔPhe-Ala-ΔPhe- Ala-OMe; A Pentapeptide with a Novelβ-Bend Ribbon Structure

Autor:	K. R. Rajashankar, Suryanarayanarao Ramakumar, Tapas K. Mal, Virander S. Chauhan
Rok vydání:	1994
Předmět:	Stereochemistry Chemistry Ribbon diagram General Medicine General Chemistry Crystal structure Pentapeptide repeat Catalysis Crystal Crystallography Ribbon Molecule sense organs Enzymatic degradation
Zdroj:	Angewandte Chemie International Edition in English. 33:970-973
ISSN:	1521-3773 0570-0833
DOI:	10.1002/anie.199409701
Popis:	Neither a helical structure nor a spiral β-bend ribbon structure, but a flat β-bend ribbon is formed by the title compound. Peptides with 2,3-didehydroamino acid esters (α,β-didehydroamino acid esters) such as dehydrophenylalanine (ΔPhe) are of great interest as model compounds for the study of structure-function relationships, since the dehydroamino acids strongly influence the conformation and the enzymatic degradation of peptides. The comparison of the structure of the title compound with that of corresponding Aib-containing peptides is informative.
Databáze:	OpenAIRE
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