Evaluation of Antidiabetic Activity of Aqueous and Etylic alcohol Extracts of Stem Bark of Xylopia villosa Chipp (Annonaceae)
| Autor: | Yapi Houphouët Félix, Kouame Yao Yves, Okpekon Aboua Timothée |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Embryology
medicine.medical_specialty Antioxidant biology Chemistry Insulin medicine.medical_treatment Cell Biology Type 2 diabetes Pharmacology medicine.disease biology.organism_classification Streptozocin Insulin receptor Endocrinology Therapeutic index Diabetes mellitus Internal medicine medicine biology.protein Anatomy Xylopia Developmental Biology |
| Zdroj: | Advances in Diabetes and Metabolism. 5:12-19 |
| ISSN: | 2332-0060 2332-0052 |
| DOI: | 10.13189/adm.2017.050103 |
| Popis: | This study aims to evaluate antidiabetic activity of aqueous and ethanolic extracts of Xylopia villosa stem bark. Induction of diabetes was made with Streptozocin on male rats. Treatments of diabetic rats with aqueous and ethanolic extracts of Xylopia villosa at doses of 100 and 200 mg / kg bw and Daonil (the reference molecule) at doses of 10 and 20 mg / kg bw revealed that ethanolic extract (200 mg / kg) bw behaved like Daonil (20 mg / kg bw). It is the therapeutic dose needed to correct hyperglycaemia. At this dose, the ethanolic extract allowed an important insulin secretion equivalent to the non-diabetic control rats and allowed the gradual reconstitution of the islets of Langerhans and the reappearance of the β cells responsible for the secretion of the insulin. This situation would be linked to the flavonoids and zinc contained in the extracts. Indeed, Zinc, in addition to being a powerful antioxidant, would have a protective insulin action and an important insulin-like effect by activating the kinases involved in insulin signaling and the phosphorylations necessary for insulin efficacy. Also, flavonoids improve the sensitivity of the body's cells to insulin, which reduces the incidence of type 2 diabetes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|