| Autor: |
Gundi Steinhilber, Mauro Novali, Giordano Bozzola, Michela Bezzi, Michele Vitacca, Luca Bianchi, Alessandra Montini, Alma Berlendis, Simona Marino, Mara Paneroni |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Interventional Pulmonology. |
| DOI: |
10.1183/1393003.congress-2017.pa806 |
| Popis: |
Bronchoscopic lung volume reduction (BLVR) is a novel emphysema therapy. Whereas Pulmonary Rehabilitation (PR) is considered mandatory before BLVR, few data exist about the methods and efficacy of PR in a longer follow up period. We retrospectively evaluated short and long-term efficacy of BLVR on pulmonary function (PF) and of repeated PR programs (PRP) on disability in patients with heterogeneous emphysema undergone BLVR with one-way valves or coils. 39 patients (BTE group) undergone BLVR with one-way valves (30 pts, mean age 66.6±1.3; FEV1%pred.=29.1±1.8; RV%pred. =243.1±9.5) or with coils (9 pts, mean age=69.0±1.4; FEV1%pred.=28.2±2.7; RV%pred.=212.4±6.9) were compared to 32 controls (mean age =70.4±1.3; FEV1%pred.= 32.7±1.5; RV%pred.= 217.8±8.3). Main functional variables improved after BLVR (difference between groups: FEV1%pred.= 3.8; 95%CI 0.1 to 7.5 p=0.043; RV%pred =20.5; 95%CI 8.1 to 32.9, p=0.02) and more significantly in patients with atelectasis. Response rate of 6-MWD was greater after BLVR in the BTE group than in controls (12/39 and 1/39, p=0.003), but not after PRP (25/39 and 18/30 in BTE and controls) and mainly due to improvement in atelectasis patients. 6-MWD improvement after the first PRP was maintained at the evaluation at 1 and 2 years after PRP in the treated group and, to a greater extent, in the atelectasis group; 6-MWD improvement 3 years after PRP was still higher in the treated group than in controls (p BLVR confirmed to be effective in improving PF, particularly in reducing RV and consequently exercise tolerance. PR following BLVR further improved exercise tolerance and repeated PRPs were able to maintain the improvement of disability in treated patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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