CYP2C9, CYP4F2, VKORC1 Gene Polymorphism in Buryat Population
| Autor: | T. A. Bairova, A. Yu. Sambyalova, O. A. Ershova, E. V. Belyaeva, D. S. Sargaeva, Sergey I. Kolesnikov |
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| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Genetics 0303 health sciences education.field_of_study VKORC1 Gene CYP4F2 Population Biology 01 natural sciences Genotype frequency law.invention 03 medical and health sciences Polymorphism (computer science) law Allele education Gene Polymerase chain reaction 030304 developmental biology 010606 plant biology & botany |
| Zdroj: | Russian Journal of Genetics. 56:1496-1503 |
| ISSN: | 1608-3369 1022-7954 |
| DOI: | 10.1134/s1022795420120121 |
| Popis: | The allele and genotype frequency distribution at polymorphic loci rs1799853 (430C>T) and rs1057910 (A1075C) of the CYP2C9 gene, rs2108622 (1347C>T) of the CYP4F2 gene, and rs9923231 (1639G>A) of the VKORC1 gene in the Buryat population was examined. The study involved 197 volunteers living in the Republic of Buryatia: 124 woman and 73 men, average age of 57.51 ± 10.88 years. Genetic typing of DNA samples was performed by polymerase chain reaction (RT-PCR). The frequency of the minor alleles *2 and *3 of the CYP2C9 gene was 2.03 and 3.05%, respectively. The frequency of the allele T of the CYP4F2 gene was 31.22%; the frequency of the allele A of the VKORC1 gene was 85.28%. The obtained results could be used in the prognosis of pharmacotherapy of warfarin in the population Buryat population. |
| Databáze: | OpenAIRE |
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